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Leicester hospital in swine flu outbreak as 14 cancer patients diagnosed with illness
Affected patients at Leicester Royal Infirmary put into isolation and given antiviral drugs as hospital wards they were in are closed
Source: The Telegraph : Swine Flu A H1N1 - February 18, 2016 Category: Infectious Diseases Tags: Leicester illness h1n1 outbreak Leicester Royal Infirmary hospital flu swine flu Source Type: news
Woman diagnoses her own ovarian cancer with Google search
Sadie Rance turns to internet search engine for answers after being told stomach pains and constipation were due to Irritable Bowel Syndrome
Source: Telegraph Health - February 6, 2015 Category: Consumer Health News Tags: search ovarian Irritable Bowel Syndrome Sadie Rance diagnosed Cancer Google Source Type: news
Obesity, risk of biochemical recurrence, and prostate ‐specific antigen doubling time after radical prostatectomy: results from the SEARCH database
ConclusionWhile we confirmed that higher BMI was associated with BCR, we found no link between BMI and PSADT at the time of recurrence. Our data suggest obese men do not have more aggressive recurrences. Future studies are needed to test whether obesity predicts response to salvage therapies.
Source: BJU International - November 16, 2018 Category: Urology & Nephrology Authors: Stephen J. Freedland,
Brandee L. Branche,
Lauren E. Howard,
Robert J. Hamilton,
William J. Aronson,
Martha K. Terris,
Matthew R. Cooperberg,
Christopher L. Amling,
Christopher J. Kane,
On behalf of the SEARCH Database Study Group Tags: Original Article Source Type: research
Cardiovascular Parameters in a Swine Model of Normobaric Hypoxia Treated With 5-Hydroxymethyl-2-Furfural (5-HMF)
Conclusion: 5-HMF treatment decreased P50, improved SaO2, and mitigated increases in PAP in this swine model of NH.
Introduction
The reduction of barometric pressure at altitude is associated with reduced partial pressure of ambient Oxygen (PO2). With lower ambient PO2, it can be anticipated that alveolar (PAO2), arterial O2 (PaO2) and blood O2 content (CaO2) will decrease accordingly, resulting in a widely recognized decrease in maximal O2 consumption (VO2) (Dill and Adams, 1972; Lucas et al., 2011). In humans, with acute exposure to altitude, maximal VO2 decrements are measurable at elevations even as low as 580 ...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research
Experimental study in vivo ablation of swine pancreas using high-intensity focused ultrasound
Conclusions: It was feasible and safe to use HIFU for ablation of the pancreas in swine.
Source: Journal of Cancer Research and Therapeutics - March 31, 2019 Category: Cancer & Oncology Authors: Guanghui Huang Xin Ye Xia Yang Aimin Zheng Wenhong Li Jiao Wang Xiaoying Han Zhigang Wei Min Meng Yang Ni Chengkun Qin Xingbo Fei Liulin Xiong Source Type: research
Cellular Therapies for the Treatment of Hematological Malignancies; Swine Are an Ideal Preclinical Model
The absence of clinically relevant large animal tumor models has historically forced experimental cellular therapies for hematological malignancies to translate directly from murine models to clinical trials. However, recent advances highlight swine as an ideal large animal model to demonstrate the safety of murine proof of concept studies prior to their implementation clinically. The availability of the MHC defined MGH miniature swine herd has been key for the development of novel approaches for hematopoietic cell and solid organ transplantation. New spontaneously arising hematological malignancies in these swine, specifi...
Source: Frontiers in Oncology - June 20, 2019 Category: Cancer & Oncology Source Type: research
Miniature Swine for Preclinical Modeling of Complexities of Human Disease for Translational Scientific Discovery and Accelerated Development of Therapies and Medical Devices.
Abstract
Noncommunicable diseases, including cardiovascular disease, diabetes, chronic respiratory disease, and cancer, are the leading cause of death in the world. The cost, both monetary and time, of developing therapies to prevent, treat, or manage these diseases has become unsustainable. A contributing factor is inefficient and ineffective preclinical research, in which the animal models utilized do not replicate the complex physiology that influences disease. An ideal preclinical animal model is one that responds similarly to intrinsic and extrinsic influences, providing high translatability and concordance o...
Source: Toxicologic Pathology - February 2, 2016 Category: Pathology Authors: Schomberg DT, Tellez A, Meudt JJ, Brady DA, Dillon KN, Arowolo FK, Wicks J, Rousselle SD, Shanmuganayagam D Tags: Toxicol Pathol Source Type: research
Wild-type p53-induced phosphatase 1 (WIP1) regulates the proliferation of swine Sertoli cells through P53.
Abstract
Wild-type p53-induced phosphatase 1 (WIP1) plays an oncogenic function by increasing cell proliferation in various cancer types. Deficiency in WIP1 expression leads to male infertility, possibly by impairing the blood-testis barrier and spermatogenesis. However, how WIP1 functions in the Sertoli cells to affect male reproduction remains unclear. Thus, in the present study we used a swine Sertoli cell line to investigate whether WIP1 regulated the proliferation of Sertoli cells to participate in male reproduction. The WIP1 inhibitor GSK2830371, WIP1-short interference (si) RNAs and an upstream microRNA (mi...
Source: Reproduction, Fertility, and Development - December 8, 2020 Category: Reproduction Medicine Authors: Wang B, Zhang M, Che J, Li K, Mu Y, Liu Z Tags: Reprod Fertil Dev Source Type: research
Intraoperative laparoscopic detection of sentinel lymph nodes with indocyanine green and superparamagnetic iron oxide in a swine gallbladder cancer model
In conclusion, detecting the SLNs of gallbladder cancerin situ using a dual tracer laparoscopic technique with ICG and SPIO was feasible in a swine model.
Source: PLoS One - March 11, 2021 Category: Biomedical Science Authors: Kisyo Mihara Source Type: research
Recombinant hemagglutinin of swine H1N1 influenza virus expression in the insect cells: Formulation in Montanide ISA71 adjuvant and the potency studies
CONCLUSION: To summarize, the results showed that the recombinant protein with the MontanideTM ISA- 71 adjuvant developed a more appropriate level of immunity than Alum adjuvant, so it might be used as a safe and reliable vaccine against H1N1 virus for further research.PMID:35317113 | PMC:PMC8917850 | DOI:10.22038/IJBMS.2021.57053.12716
Source: Cancer Control - March 23, 2022 Category: Cancer & Oncology Authors: Sara Zahmati Morteza Taghizadeh Setareh Haghighat Reza Jalalirad Mehdi Mahdavi Source Type: research
Self-regulating novel iron oxide nanoparticle-based magnetic hyperthermia in swine: biocompatibility, biodistribution, and safety assessments
Arch Toxicol. 2022 May 30. doi: 10.1007/s00204-022-03314-1. Online ahead of print.ABSTRACTStudies demonstrating the successful and safe application of magnetic hyperthermia in large animals are scarce. A therapeutic approach for advanced cancer comprising multicore encapsulated iron oxide (IO) Sarah Nanoparticles (SaNPs), that uniquely self-regulate their temperature, was developed thus overcoming the safety challenges of hyperthermia. SaNPs are intravenously injected and accumulate in tumor tissue, leading to selective heating upon exposure to an external alternating magnetic field (AMF). A series of studies were conducte...
Source: Archives of Toxicology - May 31, 2022 Category: Toxicology Authors: Sarah Kraus Ricarina Rabinovitz Ekaterina Sigalov Moshe Eltanani Raz Khandadash Cheri Tal Ofra Rivlin Eddie Sharaga Pazit Rukenstein Moshe Cohen-Erner Abraham Nyska Yariv Siman-Tov Ofer Shalev Source Type: research
Molecular characterization, tissue expression profile, and single nucleotide polymorphism analysis of the periostin gene in swine.
Abstract
Periostin, also called osteoblast-specific factor 2, is an important regulator of bone, cardiac development, and wound healing. A recent study revealed that periostin plays an important role in tumor development and is upregulated in a wide variety of cancers. However, little is known about periostin in swine. Therefore, the cDNA sequence of the porcine periostin gene was obtained by rapid amplification of cDNA ends (RACE). One C/T single nucleotide polymorphism anchored in intron 9 was identified and genotyped by PCR-RFLP-HaeIII. In Daweizi, Shaziling, Ningxiang, Taoyuan, Wuzhishan, Landrace, and Yorkshi...
Source: Genetics and Molecular Research - March 19, 2016 Category: Genetics & Stem Cells Authors: Xu D, Ma HM, Xiao DF Tags: Genet Mol Res Source Type: research
Serial retrograde instillations of sustained release formulation of mitomycin C to the upper urinary tract of the Yorkshire swine using a thermosensitive polymer: Safety and feasibility.
CONCLUSIONS: Serial retrograde instillations of MitoGel to the pyelocaliceal system were technically feasible, and produced no observable adverse clinical, laboratory, or histologic effects.
PMID: 28065395 [PubMed - as supplied by publisher]
Source: Urologic Oncology - January 2, 2017 Category: Urology & Nephrology Authors: Donin NM, Strauss-Ayali D, Agmon-Gerstein Y, Malchi N, Lenis AT, Holden S, Pantuck AJ, Belldegrun AS, Chamie K Tags: Urol Oncol Source Type: research
Intraoperative Cerenkov Luminescence Imaging for Image-Guided Resection of Low Rectal Cancer on Swine Models
Conclusions An intraoperative CLI system with high resolution and sensitivity was successfully developed for image-guided resection of low rectal cancer on swine models. The intraoperative CLI system exhibits high potential for image-guided resection of low rectal cancer in clinic. Parameters of the intraoperative CLI systemSystem featuresPerformance parametersWorking distance (mm)40-300Surgical field of view (mm)70[asterisk]70-130[asterisk]130Resolution (mm)0.07Sensibility (µCi/ml)0.5Image windowsVisible, Cerenkov luminescence, overlay
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Hu, Z., Zhang, Z., Guo, H., Tian, J. Tags: Multimodal and Technical Approach for Tumor Detection and Response Assessment Source Type: research
